Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms

The ε4-allele variant of apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer’s disease, although it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation of plaques and neurofibrillary tangles, the structural...

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Detalles Bibliográficos
Autores principales: Stuchell-Brereton, Melissa D., Zimmerman, Maxwell I., Miller, Justin J., Mallimadugula, Upasana L., Incicco, J. Jeremías, Roy, Debjit, Smith, Louis G., Cubuk, Jasmine, Baban, Berevan, DeKoster, Gregory T., Frieden, Carl, Bowman, Gregory R., Soranno, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963066/
https://www.ncbi.nlm.nih.gov/pubmed/36749730
http://dx.doi.org/10.1073/pnas.2215371120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963066/
https://www.ncbi.nlm.nih.gov/pubmed/36749730
http://dx.doi.org/10.1073/pnas.2215371120

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