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The marionette mechanism of domain–domain communication in the antagonist, agonist, and coactivator responses of the estrogen receptor
The human estrogen receptor α (hERα) is involved in the regulation of growth, development, and tissue homeostasis. Agonists that bind to the receptor’s ligand-binding domain (LBD) lead to recruitment of coactivators and the enhancement of gene expression. In contrast, antagonists bind to the LBD and...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963092/ https://www.ncbi.nlm.nih.gov/pubmed/36730193 http://dx.doi.org/10.1073/pnas.2216906120 |