Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility

Combretastatin A-4 (CA-4) is a potent tubulin polymerisation inhibitor. However, the clinical application of CA-4 is limited owing to its low aqueous solubility and the easy conversion of the olefin double bond from the more active cis- to the less active trans-configuration. Several structural modi...

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Detalles Bibliográficos
Autores principales: Chen, Zhi-Hao, Xu, Run-Mei, Zheng, Guang-Hao, Jin, Ye-Zhi, Li, Yuan, Chen, Xin-Yuan, Tian, Yu-Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963121/
https://www.ncbi.nlm.nih.gov/pubmed/36838705
http://dx.doi.org/10.3390/molecules28041717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963121/
https://www.ncbi.nlm.nih.gov/pubmed/36838705
http://dx.doi.org/10.3390/molecules28041717

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