Cargando…

Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility

Combretastatin A-4 (CA-4) is a potent tubulin polymerisation inhibitor. However, the clinical application of CA-4 is limited owing to its low aqueous solubility and the easy conversion of the olefin double bond from the more active cis- to the less active trans-configuration. Several structural modi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zhi-Hao, Xu, Run-Mei, Zheng, Guang-Hao, Jin, Ye-Zhi, Li, Yuan, Chen, Xin-Yuan, Tian, Yu-Shun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963121/ https://www.ncbi.nlm.nih.gov/pubmed/36838705 http://dx.doi.org/10.3390/molecules28041717

Ejemplares similares

Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents
por: Hura, Neha, et al.
Publicado: (2018)

Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents
por: Zheng, Shilong, et al.
Publicado: (2014)

Exploring Diverse-Ring Analogues on Combretastatin A4 (CA-4) Olefin as Microtubule-Targeting Agents
por: Song, Ming-Yu, et al.
Publicado: (2020)

Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors
por: Kumar, Sunil, et al.
Publicado: (2013)

Synthesis and Cytotoxic Activity of a New Group of Heterocyclic Analogues of the Combretastatins
por: Lipeeva, Alla V., et al.
Publicado: (2014)

Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent
por: Guimarães, Celina de Jesus, et al.
Publicado: (2023)

Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
por: Zaki, Islam, et al.
Publicado: (2022)

Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents
por: Duan, Yong-Tao, et al.
Publicado: (2016)

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
por: de Lima Neto, Jorge, et al.
Publicado: (2023)

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity
por: Assali, Mohyeddin, et al.
Publicado: (2019)

Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues
por: Fayad, Eman, et al.
Publicado: (2023)

Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish
por: Shi, Yun-Wei, et al.
Publicado: (2016)

Docking, Synthesis and Antiproliferative Activity of N-Acylhydrazone Derivatives Designed as Combretastatin A4 Analogues
por: do Amaral, Daniel Nascimento, et al.
Publicado: (2014)

Design and synthesis of novel oridonin analogues as potent anticancer agents
por: Shen, Qing-Kun, et al.
Publicado: (2018)

Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity
por: Ibrahim, Tarek S., et al.
Publicado: (2020)

Finding an efficient tetramethylated hydroxydiethylene of resveratrol analogue for potential anticancer agent
por: Xin, Zhen-Hui, et al.
Publicado: (2020)

Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents
por: Li, Daichun, et al.
Publicado: (2022)

Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects
por: Jiang, Hong, et al.
Publicado: (2019)

Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues
por: Wen, Zhiyong, et al.
Publicado: (2016)

Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies
por: Egharevba, Godshelp O., et al.
Publicado: (2022)

Design, synthesis and evaluation of novel enzalutamide analogues as potential anticancer agents
por: Bhole, Ritesh P., et al.
Publicado: (2021)

Polymeric Micelles Formulation of Combretastatin Derivatives with Enhanced Solubility, Cytostatic Activity and Selectivity against Cancer Cells
por: Zlotnikov, Igor D., et al.
Publicado: (2023)

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4
por: Malebari, Azizah M., et al.
Publicado: (2021)

An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells in vitro
por: Abodo Onambele, Liliane, et al.
Publicado: (2022)

In silico design and evaluation of novel 5-fluorouracil analogues as potential anticancer agents
por: Chowdhury, Surid Mohammad, et al.
Publicado: (2020)

Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications
por: Karatoprak, Gökçe Şeker, et al.
Publicado: (2020)

Cytotoxicity Studies of Novel Combretastatin and Pterostilbene Derivatives
por: Jakubowska, Joanna, et al.
Publicado: (2014)

Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation
por: Kelly, Patrick M., et al.
Publicado: (2017)

Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents
por: Ma, Mingyi, et al.
Publicado: (2013)

Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents
por: Tomar, Vartika, et al.
Publicado: (2019)

Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents
por: Baharloui, Maryam, et al.
Publicado: (2019)

The anti-angiogenic effect and novel mechanisms of action of Combretastatin A-4
por: Su, Min, et al.
Publicado: (2016)

Anti-vascular agent Combretastatin A-4-P modulates Hypoxia Inducible Factor-1 and gene expression
por: Dachs, Gabi U, et al.
Publicado: (2006)

The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate
por: Holmes, Toby, et al.
Publicado: (2020)

Synthesis and Biological Activity Screening of Newly Synthesized Trimethoxyphenyl-Based Analogues as Potential Anticancer Agents
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Novel Isoxazole-Amide Analogues as Anticancer and Antioxidant Agents
por: Eid, Ahmad M., et al.
Publicado: (2021)

Synthesis and characterisation of (Z)-styrylbenzene derivatives as potential selective anticancer agents
por: Xin, Ya-Bing, et al.
Publicado: (2018)

Galactose Modified Liposomes for Effective Co-Delivery of Doxorubicin and Combretastatin A4
por: Lian, Bo, et al.
Publicado: (2021)

Combretastatin A4 disodium phosphate-induced myocardial injury
por: Tochinai, Ryota, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cd8sf7qti4vijos1ohkoogh1un