Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration

New strategies facilitate the design of cyclic peptides which can penetrate the brain. We have designed a bicyclic peptide, OL-CTOP, composed of the sequences of a selective μ-opioid receptor antagonist, CTOP (f-cyclo(CYwOTX)T) (X = penicillamine, Pen; O = ornithine) and odorranalectin, OL (YASPK-cy...

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Detalles Bibliográficos
Autores principales: Rayala, Ramanjaneyulu, Tiller, Annika, Majumder, Shahayra A., Stacy, Heather M., Eans, Shainnel O., Nedovic, Aleksandra, McLaughlin, Jay P., Cudic, Predrag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963138/
https://www.ncbi.nlm.nih.gov/pubmed/36838810
http://dx.doi.org/10.3390/molecules28041822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963138/
https://www.ncbi.nlm.nih.gov/pubmed/36838810
http://dx.doi.org/10.3390/molecules28041822

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