Prediction of Unwanted Crystallization of Freeze-Dried Protein Formulations Using α-Relaxation Measurements

There is a lack of methods to predict the isothermal crystallization behavior of amorphous freeze-dried formulations stored below the glass transition temperature. This study applies isothermal microcalorimetry to predict long-term crystallization during product storage time. The relaxation curve of...

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Detalles Bibliográficos
Autores principales: Groël, Sebastian, Menzen, Tim, Winter, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963158/
https://www.ncbi.nlm.nih.gov/pubmed/36840026
http://dx.doi.org/10.3390/pharmaceutics15020703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963158/
https://www.ncbi.nlm.nih.gov/pubmed/36840026
http://dx.doi.org/10.3390/pharmaceutics15020703

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