Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch

The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of DNA demethylation. To define the in vivo consequences of complete TET deficiency, we inducibly deleted all three Tet genes i...

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Detalles Bibliográficos
Autores principales: Yuita, Hiroshi, López-Moyado, Isaac F., Jeong, Hyeongmin, Cheng, Arthur Xiuyuan, Scott-Browne, James, An, Jungeun, Nakayama, Toshinori, Onodera, Atsushi, Ko, Myunggon, Rao, Anjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963276/
https://www.ncbi.nlm.nih.gov/pubmed/37406303
http://dx.doi.org/10.1073/pnas.2214824120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963276/
https://www.ncbi.nlm.nih.gov/pubmed/37406303
http://dx.doi.org/10.1073/pnas.2214824120

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