Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse

Ligation of T cell receptor (TCR) to peptide–MHC (pMHC) complexes initiates signaling leading to T cell activation and TCR ubiquitination. Ubiquitinated TCR is then either internalized by the T cell or released toward the antigen-presenting cell (APC) in extracellular vesicles. How these distinct fa...

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Detalles Bibliográficos
Autores principales: Kvalvaag, Audun, Valvo, Salvatore, Céspedes, Pablo F, Saliba, David G, Kurz, Elke, Korobchevskaya, Kseniya, Dustin, Michael L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963302/
https://www.ncbi.nlm.nih.gov/pubmed/36730202
http://dx.doi.org/10.1073/pnas.2211368120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963302/
https://www.ncbi.nlm.nih.gov/pubmed/36730202
http://dx.doi.org/10.1073/pnas.2211368120

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