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Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse
Ligation of T cell receptor (TCR) to peptide–MHC (pMHC) complexes initiates signaling leading to T cell activation and TCR ubiquitination. Ubiquitinated TCR is then either internalized by the T cell or released toward the antigen-presenting cell (APC) in extracellular vesicles. How these distinct fa...
Autores principales: | Kvalvaag, Audun, Valvo, Salvatore, Céspedes, Pablo F, Saliba, David G, Kurz, Elke, Korobchevskaya, Kseniya, Dustin, Michael L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963302/ https://www.ncbi.nlm.nih.gov/pubmed/36730202 http://dx.doi.org/10.1073/pnas.2211368120 |
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