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Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response
KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance, leading to their low immunogenicity. To overcome t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963332/ https://www.ncbi.nlm.nih.gov/pubmed/36838925 http://dx.doi.org/10.3390/molecules28041934 |
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author | Liu, Yang Li, Bohan Zheng, Xiujing Xiong, Decai Ye, Xinshan |
author_facet | Liu, Yang Li, Bohan Zheng, Xiujing Xiong, Decai Ye, Xinshan |
author_sort | Liu, Yang |
collection | PubMed |
description | KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance, leading to their low immunogenicity. To overcome these problems, some fluorinated derivatives of the KH-1 antigen were designed, synthesized, and conjugated to the carrier protein CRM197 to form glycoconjugates, which were used for immunological studies with Freund’s adjuvant. The results showed that fluorine-modified N-acyl KH-1 conjugates can induce higher titers of antibodies, especially IgG, which can recognize KH-1-positive cancer cells and can eliminate cancer cells through complement-dependent cytotoxicity (CDC). The trifluoro-modified KH-1-TF-CRM197 showed great potential as an anticancer vaccine candidate. |
format | Online Article Text |
id | pubmed-9963332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99633322023-02-26 Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response Liu, Yang Li, Bohan Zheng, Xiujing Xiong, Decai Ye, Xinshan Molecules Article KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance, leading to their low immunogenicity. To overcome these problems, some fluorinated derivatives of the KH-1 antigen were designed, synthesized, and conjugated to the carrier protein CRM197 to form glycoconjugates, which were used for immunological studies with Freund’s adjuvant. The results showed that fluorine-modified N-acyl KH-1 conjugates can induce higher titers of antibodies, especially IgG, which can recognize KH-1-positive cancer cells and can eliminate cancer cells through complement-dependent cytotoxicity (CDC). The trifluoro-modified KH-1-TF-CRM197 showed great potential as an anticancer vaccine candidate. MDPI 2023-02-17 /pmc/articles/PMC9963332/ /pubmed/36838925 http://dx.doi.org/10.3390/molecules28041934 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Yang Li, Bohan Zheng, Xiujing Xiong, Decai Ye, Xinshan Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response |
title | Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response |
title_full | Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response |
title_fullStr | Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response |
title_full_unstemmed | Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response |
title_short | Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response |
title_sort | cancer vaccines based on fluorine-modified kh-1 elicit robust immune response |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963332/ https://www.ncbi.nlm.nih.gov/pubmed/36838925 http://dx.doi.org/10.3390/molecules28041934 |
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