Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils

The amyloid aggregation of alpha-synuclein within the brain is associated with the pathogenesis of Parkinson’s disease (PD) and other related synucleinopathies, including multiple system atrophy (MSA). Alpha-synuclein aggregates are a major therapeutic target for treatment of these diseases. We iden...

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Detalles Bibliográficos
Autores principales: Murray, Kevin A., Hu, Carolyn J., Pan, Hope, Lu, Jiahui, Abskharon, Romany, Bowler, Jeannette T., Rosenberg, Gregory M., Williams, Christopher K., Elezi, Gazmend, Balbirnie, Melinda, Faull, Kym F., Vinters, Harry V., Seidler, Paul M., Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963379/
https://www.ncbi.nlm.nih.gov/pubmed/36757890
http://dx.doi.org/10.1073/pnas.2217835120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963379/
https://www.ncbi.nlm.nih.gov/pubmed/36757890
http://dx.doi.org/10.1073/pnas.2217835120

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