Cargando…

Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven valuable for studies of kidney development, disease, and therapeutic screening. However, specific applications have been hampered by limited expansion capacity, immaturity, off-target cells, and inability to access the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yousef Yengej, Fjodor A., Jansen, Jitske, Ammerlaan, Carola M. E., Dilmen, Emre, Pou Casellas, Carla, Masereeuw, Rosalinde, Hoenderop, Joost G., Smeets, Bart, Rookmaaker, Maarten B., Verhaar, Marianne C., Clevers, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963523/ https://www.ncbi.nlm.nih.gov/pubmed/36724260 http://dx.doi.org/10.1073/pnas.2216836120

Ejemplares similares

Kidney Organoids and Tubuloids
por: Yousef Yengej, Fjodor A., et al.
Publicado: (2020)

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids
por: Lindoso, Rafael Soares, et al.
Publicado: (2022)

Differentiated mouse kidney tubuloids as a novel in vitro model to study collecting duct physiology
por: Olde Hanhof, C. J. A., et al.
Publicado: (2023)

Substrate Stiffness Determines the Establishment of Apical-Basal Polarization in Renal Epithelial Cells but Not in Tubuloid-Derived Cells
por: Hagelaars, Maria J., et al.
Publicado: (2022)

Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
por: Jamalpoor, Amer, et al.
Publicado: (2021)

Spinach and Chive for Kidney Tubule Engineering: the Limitations of Decellularized Plant Scaffolds and Vasculature
por: Jansen, Katja, et al.
Publicado: (2020)

Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids
por: Martinez-Silgado, Adriana, et al.
Publicado: (2022)

“3D, human renal proximal tubule (RPTEC-TERT1) organoids ‘tubuloids’ for translatable evaluation of nephrotoxins in high-throughput”
por: Vidal Yucha, Sarah E., et al.
Publicado: (2022)

Author Correction: Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs
por: Pou Casellas, Carla, et al.
Publicado: (2023)

Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs
por: Pou Casellas, Carla, et al.
Publicado: (2023)

Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies
por: Vermue, IJsbrand M., et al.
Publicado: (2021)

Quantification of cystine in human renal proximal tubule cells using liquid chromatography–tandem mass spectrometry
por: Jamalpoor, Amer, et al.
Publicado: (2018)

Using human iPSC-derived kidney organoids to decipher SARS-CoV-2 pathology on single cell level
por: Reimer, Katharina C., et al.
Publicado: (2022)

Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application
por: Mihajlovic, Milos, et al.
Publicado: (2017)

Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently
por: Schophuizen, Carolien M. S., et al.
Publicado: (2015)

Merits and challenges of iPSC-derived organoids for clinical applications
por: Xu, Ziran, et al.
Publicado: (2023)

Bioengineered Kidney Tubules Efficiently Clear Uremic Toxins in Experimental Dialysis Conditions
por: Faria, João, et al.
Publicado: (2023)

iPSC-Derived Organoids as Therapeutic Models in Regenerative Medicine and Oncology
por: Turhan, Ali G., et al.
Publicado: (2021)

Application of an iPSC‐Derived Organoid Model for Localized Scleroderma Therapy
por: Ma, Jie, et al.
Publicado: (2022)

iPSC-derived mesenchymal cells that support alveolar organoid development
por: Tamai, Koji, et al.
Publicado: (2022)

Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype
por: Sendino Garví, Elena, et al.
Publicado: (2022)

Generation and validation of APOE knockout human iPSC-derived cerebral organoids
por: Martens, Yuka A., et al.
Publicado: (2021)

Human iPSC colon organoid function is improved by exposure to fecal fermentates
por: Pearce, Sarah C., et al.
Publicado: (2022)

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
por: Miki, Kenji, et al.
Publicado: (2021)

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability
por: Chandrasekaran, Vidya, et al.
Publicado: (2021)

The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells
por: Yang, Yi, et al.
Publicado: (2023)

Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance
por: van Genderen, Anne Metje, et al.
Publicado: (2021)

Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids
por: Sun, Guoqiang, et al.
Publicado: (2020)

Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids
por: Costamagna, Gianluca, et al.
Publicado: (2021)

“iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives”
por: Roman, Giacomo, et al.
Publicado: (2023)

iPSC-derived three-dimensional brain organoid models and neurotropic viral infections
por: Swingler, Michael, et al.
Publicado: (2023)

In depth characterization of midbrain organoids derived from wild type iPSC lines
por: Pavlinov, Ivan, et al.
Publicado: (2023)

Development of lacrimal gland organoids from iPSC derived multizonal ocular cells
por: Asal, Melis, et al.
Publicado: (2023)

Protein-Bound Uremic Toxins Induce Reactive Oxygen Species-Dependent and Inflammasome-Mediated IL-1β Production in Kidney Proximal Tubule Cells
por: Mihajlovic, Milos, et al.
Publicado: (2021)

The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model
por: Zayat, Valery, et al.
Publicado: (2023)

Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids
por: Lane, Amelia, et al.
Publicado: (2020)

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids
por: McClements, Michelle E., et al.
Publicado: (2022)

Enhanced Microvasculature Formation and Patterning in iPSC–Derived Kidney Organoids Cultured in Physiological Hypoxia
por: Schumacher, Anika, et al.
Publicado: (2022)

Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models
por: Pranty, Abida Islam, et al.
Publicado: (2022)

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion
por: Jansen, Jitske, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_j56b22s68s3n7kbnc5semnpl92