Design, Characterization and Pharmacokinetic–Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of Nebivolol for Treatment of Open-Angle Glaucoma

This study developed a dual-responsive in situ gel of nebivolol (NEB), a selective β-adrenergic antagonist. The gel could achieve sustained concentrations in the aqueous humor to effectively treat glaucoma. The gel was prepared using a combination of poloxamers (Poloxamer-407 (P407) and Poloxamer-18...

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Detalles Bibliográficos
Autores principales: Rawat, Pradeep Singh, Ravi, Punna Rao, Mir, Shahid Iqbal, Khan, Mohammed Shareef, Kathuria, Himanshu, Katnapally, Prasanna, Bhatnagar, Upendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963565/
https://www.ncbi.nlm.nih.gov/pubmed/36839727
http://dx.doi.org/10.3390/pharmaceutics15020405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963565/
https://www.ncbi.nlm.nih.gov/pubmed/36839727
http://dx.doi.org/10.3390/pharmaceutics15020405

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