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Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase

NusG is a transcription elongation factor that stimulates transcription pausing in Gram+ bacteria including B. subtilis by sequence-specific interaction with a conserved pause-inducing (−)(11)TTNTTT(−6) motif found in the non-template DNA (ntDNA) strand within the transcription bubble. To reveal the...

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Detalles Bibliográficos
Autores principales: Vishwakarma, Rishi K., Qayyum, M. Zuhaib, Babitzke, Paul, Murakami, Katsuhiko S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963633/
https://www.ncbi.nlm.nih.gov/pubmed/36745813
http://dx.doi.org/10.1073/pnas.2218516120