Cargando…

Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase

NusG is a transcription elongation factor that stimulates transcription pausing in Gram+ bacteria including B. subtilis by sequence-specific interaction with a conserved pause-inducing (−)(11)TTNTTT(−6) motif found in the non-template DNA (ntDNA) strand within the transcription bubble. To reveal the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vishwakarma, Rishi K., Qayyum, M. Zuhaib, Babitzke, Paul, Murakami, Katsuhiko S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963633/ https://www.ncbi.nlm.nih.gov/pubmed/36745813 http://dx.doi.org/10.1073/pnas.2218516120

Ejemplares similares

Robust regulation of transcription pausing in Escherichia coli by the ubiquitous elongation factor NusG
por: Yakhnin, Alexander V., et al.
Publicado: (2023)

NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA
por: Mandell, Zachary F, et al.
Publicado: (2021)

Structural insights into NusG regulating transcription elongation
por: Liu, Bin, et al.
Publicado: (2017)

NusG-Dependent RNA Polymerase Pausing and Tylosin-Dependent Ribosome Stalling Are Required for Tylosin Resistance by Inducing 23S rRNA Methylation in Bacillus subtilis
por: Yakhnin, Helen, et al.
Publicado: (2019)

NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble
por: Turtola, Matti, et al.
Publicado: (2016)

Functional analysis of Thermus thermophilus transcription factor NusG
por: Sevostyanova, Anastasiya, et al.
Publicado: (2010)

NusG, an Ancient Yet Rapidly Evolving Transcription Factor
por: Wang, Bing, et al.
Publicado: (2021)

Thermotoga maritima NusG: domain interaction mediates autoinhibition and thermostability
por: Drögemüller, Johanna, et al.
Publicado: (2017)

NusG prevents transcriptional invasion of H-NS-silenced genes
por: Bossi, Lionello, et al.
Publicado: (2019)

Escherichia coli NusG Links the Lead Ribosome with the Transcription Elongation Complex
por: Washburn, Robert S., et al.
Publicado: (2020)

Origins and Molecular Evolution of the NusG Paralog RfaH
por: Wang, Bing, et al.
Publicado: (2020)

Mycobacterial RNA Polymerase Requires a U-Tract at Intrinsic Terminators and Is Aided by NusG at Suboptimal Terminators
por: Czyz, Agata, et al.
Publicado: (2014)

Transcription is regulated by NusA:NusG interaction
por: Strauß, Martin, et al.
Publicado: (2016)

A Nexus for Gene Expression—Molecular Mechanisms of Spt5 and NusG in the Three Domains of Life
por: Werner, Finn
Publicado: (2012)

Many dissimilar NusG protein domains switch between α-helix and β-sheet folds
por: Porter, Lauren L., et al.
Publicado: (2022)

Structural Basis for NusA Stabilized Transcriptional Pausing
por: Guo, Xieyang, et al.
Publicado: (2018)

RNA polymerase-induced remodelling of NusA produces a pause enhancement complex
por: Ma, Cong, et al.
Publicado: (2015)

Structural basis for RNA recognition by NusB and NusE in the initiation of transcription antitermination
por: Stagno, Jason R., et al.
Publicado: (2011)

CDK9-dependent RNA polymerase II pausing controls transcription initiation
por: Gressel, Saskia, et al.
Publicado: (2017)

The structure and activities of the archaeal transcription termination factor Eta detail vulnerabilities of the transcription elongation complex
por: Marshall, Craig J., et al.
Publicado: (2022)

On the stability of stalled RNA polymerase and its removal by RapA
por: Portman, James R, et al.
Publicado: (2022)

Structural basis of RNA polymerase recycling by the Swi2/Snf2 family of ATPase RapA in Escherichia coli
por: Qayyum, M. Zuhaib, et al.
Publicado: (2021)

Structural and mechanistic basis of σ-dependent transcriptional pausing
por: Pukhrambam, Chirangini, et al.
Publicado: (2022)

Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase
por: Shin, Yeonoh, et al.
Publicado: (2020)

A novel phage-encoded transcription antiterminator acts by suppressing bacterial RNA polymerase pausing
por: Berdygulova, Zhanna, et al.
Publicado: (2012)

In transcription antitermination by Qλ, NusA induces refolding of Qλ to form a nozzle that extends the RNA polymerase RNA-exit channel
por: Yin, Zhou, et al.
Publicado: (2022)

RNA Polymerase Pausing during Initial Transcription
por: Duchi, Diego, et al.
Publicado: (2016)

Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination
por: Burmann, Björn M., et al.
Publicado: (2010)

Splicing-Dependent RNA Polymerase Pausing in Yeast
por: Alexander, Ross D., et al.
Publicado: (2010)

The elemental mechanism of transcriptional pausing
por: Saba, Jason, et al.
Publicado: (2019)

RNA polymerase II pausing in development: orchestrating transcription
por: Abuhashem, Abderhman, et al.
Publicado: (2022)

N protein from lambdoid phages transforms NusA into an antiterminator by modulating NusA-RNA polymerase flap domain interactions
por: Mishra, Saurabh, et al.
Publicado: (2015)

Structural basis of ribosomal RNA transcription regulation
por: Shin, Yeonoh, et al.
Publicado: (2021)

Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
por: Gabizon, Ronen, et al.
Publicado: (2018)

Structural transitions in the transcription elongation complexes of bacterial RNA polymerase during σ-dependent pausing
por: Zhilina, Ekaterina, et al.
Publicado: (2012)

Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II
por: Lux, C., et al.
Publicado: (2005)

Transcriptional pause extension benefits the stand-by rather than catch-up Rho-dependent termination
por: Song, Eunho, et al.
Publicado: (2023)

SuhB is an integral part of the ribosomal antitermination complex and interacts with NusA
por: Dudenhoeffer, Benjamin R, et al.
Publicado: (2019)

Misincorporation by RNA polymerase is a major source of transcription pausing in vivo
por: James, Katherine, et al.
Publicado: (2017)

Role of RNA Polymerase II Promoter-Proximal Pausing in Viral Transcription
por: Whelan, Marilyn, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3g8lvcsl08o8k28c0rrrnsbmsj