Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice with glioblastoma. Through single-cell RNA sequencing, intravital imaging, and CD8(+) T cell blocking studies in mice, we demonstrated that thi...

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Detalles Bibliográficos
Autores principales: Datta, Meenal, Chatterjee, Sampurna, Perez, Elizabeth M., Gritsch, Simon, Roberge, Sylvie, Duquette, Mark, Chen, Ivy X., Naxerova, Kamila, Kumar, Ashwin S., Ghosh, Mitrajit, Emblem, Kyrre E., Ng, Mei R., Ho, William W., Kumar, Pragya, Krishnan, Shanmugarajan, Dong, Xinyue, Speranza, Maria C., Neagu, Martha R., Iorgulescu, J. Bryan, Huang, Raymond Y., Youssef, Gilbert, Reardon, David A., Sharpe, Arlene H., Freeman, Gordon J., Suvà, Mario L., Xu, Lei, Jain, Rakesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963691/
https://www.ncbi.nlm.nih.gov/pubmed/36724255
http://dx.doi.org/10.1073/pnas.2219199120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963691/
https://www.ncbi.nlm.nih.gov/pubmed/36724255
http://dx.doi.org/10.1073/pnas.2219199120

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