Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone

Myopathy is the main adverse effect of the widely prescribed statin drug class. Statins exert their beneficial effect by inhibiting HMG CoA-reductase, the rate-controlling enzyme of the mevalonate pathway. The mechanism of statin myopathy is yet to be resolved, and its treatment is insufficient. Thr...

Descripción completa

Detalles Bibliográficos
Autores principales: Yogev, Yuval, Shorer, Zamir, Koifman, Arie, Wormser, Ohad, Drabkin, Max, Halperin, Daniel, Dolgin, Vadim, Proskorovski-Ohayon, Regina, Hadar, Noam, Davidov, Geula, Nudelman, Hila, Zarivach, Raz, Shelef, Ilan, Perez, Yonatan, Birk, Ohad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963716/
https://www.ncbi.nlm.nih.gov/pubmed/36745799
http://dx.doi.org/10.1073/pnas.2217831120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963716/
https://www.ncbi.nlm.nih.gov/pubmed/36745799
http://dx.doi.org/10.1073/pnas.2217831120

Ejemplares similares