Gene Expression Profile as a Predictor of Seizure Liability

Analysis platforms to predict drug-induced seizure liability at an early phase of drug development would improve safety and reduce attrition and the high cost of drug development. We hypothesized that a drug-induced in vitro transcriptomics signature predicts its ictogenicity. We exposed rat cortica...

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Detalles Bibliográficos
Autores principales: Lipponen, Anssi, Kajevu, Natallie, Natunen, Teemu, Ciszek, Robert, Puhakka, Noora, Hiltunen, Mikko, Pitkänen, Asla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963992/
https://www.ncbi.nlm.nih.gov/pubmed/36835526
http://dx.doi.org/10.3390/ijms24044116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963992/
https://www.ncbi.nlm.nih.gov/pubmed/36835526
http://dx.doi.org/10.3390/ijms24044116

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