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Propagation of SARS-CoV-2 in a Closed Cell Culture Device: Potential GMP Compatible Production Platform for Live-Attenuated Vaccine Candidates under BSL-3 Conditions?

Live-attenuated SARS-CoV-2 vaccines present themselves as a promising approach for the induction of broad mucosal immunity. However, for initial safety assessment in clinical trials, virus production requires conditions meeting Good Manufacturing Practice (GMP) standards while maintaining biosafety...

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Detalles Bibliográficos
Autores principales: Klessing, Stephan, Peter, Antonia Sophia, Fraedrich, Kirsten, Wagner, Jannik T., Kummer, Mirko, Deutschmann, Janina, Steininger, Philipp, Steibl, Hans-Dieter, Überla, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964031/
https://www.ncbi.nlm.nih.gov/pubmed/36851610
http://dx.doi.org/10.3390/v15020397