Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model

Myotonic dystrophy type 1 (DM1), the most common form of adult muscular dystrophy, is caused by an abnormal expansion of CTG repeats in the 3′ untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The expanded repeats of the DMPK mRNA form hairpin structures in vitro, which cau...

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Detalles Bibliográficos
Autores principales: Neault, Nafisa, Ravel-Chapuis, Aymeric, Baird, Stephen D., Lunde, John A., Poirier, Mathieu, Staykov, Emiliyan, Plaza-Diaz, Julio, Medina, Gerardo, Abadía-Molina, Francisco, Jasmin, Bernard J., MacKenzie, Alex E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964082/
https://www.ncbi.nlm.nih.gov/pubmed/36835205
http://dx.doi.org/10.3390/ijms24043794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964082/
https://www.ncbi.nlm.nih.gov/pubmed/36835205
http://dx.doi.org/10.3390/ijms24043794

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