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Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PL(pro) Protein

Recent studies have shown that the peptide [des-Cys(11),Lys(12),Lys(13)-(p-BthTX-I)(2)K] (p-Bth) is a p-BthTX-I analog that shows enhanced antimicrobial activity, stability and hemolytic activity, and is easy to obtain compared to the wild-type sequence. This molecule also inhibits SARS-CoV-2 viral...

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Detalles Bibliográficos
Autores principales: Bitencourt, Natália Vitória, Righetto, Gabriela Marinho, Camargo, Ilana Lopes Baratella Cunha, de Godoy, Mariana Ortiz, Guido, Rafael Victorio Carvalho, Oliva, Glaucius, Santos-Filho, Norival Alves, Cilli, Eduardo Maffud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964244/
https://www.ncbi.nlm.nih.gov/pubmed/36839758
http://dx.doi.org/10.3390/pharmaceutics15020436