Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly, many aspects of their cell transduction pathway have been well characterized. However, the specific mechanisms that AAV virions use to enter the host nucleus remain largely unresolved. We therefore aimed to revea...

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Detalles Bibliográficos
Autores principales: Hoad, Mikayla, Cross, Emily M., Donnelly, Camilla M., Sarker, Subir, Roby, Justin A., Forwood, Jade K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964314/
https://www.ncbi.nlm.nih.gov/pubmed/36851528
http://dx.doi.org/10.3390/v15020315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964314/
https://www.ncbi.nlm.nih.gov/pubmed/36851528
http://dx.doi.org/10.3390/v15020315

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