Cargando…

Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly, many aspects of their cell transduction pathway have been well characterized. However, the specific mechanisms that AAV virions use to enter the host nucleus remain largely unresolved. We therefore aimed to revea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoad, Mikayla, Cross, Emily M., Donnelly, Camilla M., Sarker, Subir, Roby, Justin A., Forwood, Jade K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964314/ https://www.ncbi.nlm.nih.gov/pubmed/36851528 http://dx.doi.org/10.3390/v15020315

Ejemplares similares

The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import
por: Tsimbalyuk, Sofiya, et al.
Publicado: (2020)

Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
por: Roman, Noelia, et al.
Publicado: (2013)

Correction: Tsimbalyuk et al. The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import. Cells 2020, 9, 1913
por: Tsimbalyuk, Sofiya, et al.
Publicado: (2022)

Importin-7 Mediates Nuclear Trafficking of DNA in Mammalian Cells
por: Dhanoya, Arjun, et al.
Publicado: (2013)

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons
por: Döhner, Katinka, et al.
Publicado: (2018)

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A
por: Pawłowski, Rafał, et al.
Publicado: (2010)

Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain
por: Rowe, Caitlin L., et al.
Publicado: (2016)

Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal
por: Matsuura, Yoshiyuki
Publicado: (2023)

Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism
por: Donnelly, Camilla M., et al.
Publicado: (2023)

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer
por: Yang, Sundy N. Y., et al.
Publicado: (2019)

Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3
por: Rizzuti, Bruno, et al.
Publicado: (2022)

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
por: Smith, Kate M., et al.
Publicado: (2018)

A systems analysis of importin-α–β mediated nuclear protein import
por: Riddick, Gregory, et al.
Publicado: (2005)

The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores
por: Shen, Qi, et al.
Publicado: (2023)

Nuclear importin α and its physiological importance
por: Miyamoto, Yoichi, et al.
Publicado: (2012)

Importin-beta-like nuclear transport receptors
por: Ström, Anne-Christine, et al.
Publicado: (2001)

Stimulated nuclear import by β-like importins
por: Flores, Karen, et al.
Publicado: (2013)

Nuclear Entry of Hepatitis B Virus Capsids Involves Disintegration to Protein Dimers followed by Nuclear Reassociation to Capsids
por: Rabe, Birgit, et al.
Publicado: (2009)

Expression and evaluation of porcine circovirus type 2 capsid protein mediated by recombinant adeno-associated virus 8
por: Li, Shuang, et al.
Publicado: (2021)

Importin 7 and Nup358 Promote Nuclear Import of the Protein Component of Human Telomerase
por: Frohnert, Cornelia, et al.
Publicado: (2014)

The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein
por: Chen, Muhan, et al.
Publicado: (2017)

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles
por: Major, Andrew T., et al.
Publicado: (2015)

Adeno-associated virus capsid protein expression in Escherichia coli and chemically defined capsid assembly
por: Le, Dinh To, et al.
Publicado: (2019)

The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3
por: Neira, José L., et al.
Publicado: (2020)

Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels
por: Schraivogel, Daniel, et al.
Publicado: (2015)

Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution
por: Tsimbalyuk, S., et al.
Publicado: (2022)

Interaction of the Mouse Polyomavirus Capsid Proteins with Importins Is Required for Efficient Import of Viral DNA into the Cell Nucleus
por: Soldatova, Irina, et al.
Publicado: (2018)

Importin α: functions as a nuclear transport factor and beyond
por: OKA, Masahiro, et al.
Publicado: (2018)

The lactate dehydrogenase-elevating virus capsid protein is a nuclear–cytoplasmic protein
por: Mohammadi, Hakimeh, et al.
Publicado: (2009)

Identification of a Classical Bipartite Nuclear Localization Signal in the Drosophila TEA/ATTS Protein Scalloped
por: Magico, Adam C., et al.
Publicado: (2011)

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts
por: Duan, Zhiqiang, et al.
Publicado: (2018)

Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking
por: Lins-Austin, Bridget, et al.
Publicado: (2020)

Chikungunya virus capsid protein contains nuclear import and export signals
por: Thomas, Saijo, et al.
Publicado: (2013)

Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block
por: Miyamoto, Yoichi, et al.
Publicado: (2004)

Nuclear import time and transport efficiency depend on importin β concentration
por: Yang, Weidong, et al.
Publicado: (2006)

Determination of the Functional Domain Organization of the Importin α Nuclear Import Factor
por: Herold, Andrea, et al.
Publicado: (1998)

Yeast importin-β is required for nuclear import of the Mig2 repressor
por: Fernández-Cid, Alejandra, et al.
Publicado: (2012)

Promotion of importin α–mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3
por: Faul, Christian, et al.
Publicado: (2005)

USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2
por: Cai, Zeng, et al.
Publicado: (2020)

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_gi6kps20dt060qdpc1gj09qgp0