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Differential Loss of OAS Genes Indicates Diversification of Antiviral Immunity in Mammals
One of the main mechanisms of inducing an antiviral response depends on 2′-5′-oligoadenylate synthetases (OAS), which sense double-stranded RNA in the cytoplasm and activate RNase L. Mutations leading to the loss of functional OAS1 and OAS2 genes have been identified as important modifiers of the hu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964502/ https://www.ncbi.nlm.nih.gov/pubmed/36851296 http://dx.doi.org/10.3390/vaccines11020419 |