Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain

Transient receptor potential channels C4/C5 are widely expressed in the pain pathway. Here, we studied the putative analgesic efficacy of the highly selective and potent TRPC4/C5 antagonist HC-070 in rats. Inhibitory potency on human TRPC4 was assessed by using the whole-cell manual patch-clamp tech...

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Detalles Bibliográficos
Autores principales: Jalava, Niina, Kaskinoro, Janne, Chapman, Hugh, Morales, Miguel, Metsänkylä, Hanna, Heinonen, Satu-Maarit, Koivisto, Ari-Pekka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964505/
https://www.ncbi.nlm.nih.gov/pubmed/36834762
http://dx.doi.org/10.3390/ijms24043350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964505/
https://www.ncbi.nlm.nih.gov/pubmed/36834762
http://dx.doi.org/10.3390/ijms24043350

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