Biological Distribution after Oral Administration of Radioiodine-Labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs, and/or MRPs

We evaluated the whole-body distribution of orally-administered radioiodine-125 labeled acetaminophen ((125)I-AP) to estimate gastrointestinal absorption of anionic drugs. (125)I-AP was added to human embryonic kidney (HEK)293 and Flp293 cells expressing human organic anion transporting polypeptide...

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Detalles Bibliográficos
Autores principales: Sato, Kakeru, Mizutani, Asuka, Muranaka, Yuka, Yao, Jianwei, Kobayashi, Masato, Yamazaki, Kana, Nishii, Ryuichi, Nishi, Kodai, Nakanishi, Takeo, Tamai, Ikumi, Kawai, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964641/
https://www.ncbi.nlm.nih.gov/pubmed/36839818
http://dx.doi.org/10.3390/pharmaceutics15020497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964641/
https://www.ncbi.nlm.nih.gov/pubmed/36839818
http://dx.doi.org/10.3390/pharmaceutics15020497

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