Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan is a potential combination therapy. In this work, a novel series of 3,5-disubstituted thiazolidine-2,4-diones was synthesized and tested agai...

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Detalles Bibliográficos
Autores principales: Ivankin, Dmitry I., Kornienko, Tatyana E., Mikhailova, Marina A., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Achara, Chigozie, Reynisson, Jóhannes, Golyshev, Victor M., Luzina, Olga A., Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964680/
https://www.ncbi.nlm.nih.gov/pubmed/36835244
http://dx.doi.org/10.3390/ijms24043834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964680/
https://www.ncbi.nlm.nih.gov/pubmed/36835244
http://dx.doi.org/10.3390/ijms24043834

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