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Developing In Situ Chemometric Models with Raman Spectroscopy for Monitoring an API Disproportionation with a Complex Polymorphic Landscape
An in situ Raman method was developed to characterize the disproportionation of two salts involving a complex polymorphic landscape comprising up to two metastable and one stable freebase forms. Few precedents exist for Raman calibration procedures for solid form quantitation involving more than two...
Autores principales: | Mohan, Shikhar, Li, Yi, Chu, Kevin, Shi, Bing, De La Paz, Liliana, Bakre, Prarthana, Foti, Chris, Rucker, Victor, Lai, Chiajen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964727/ https://www.ncbi.nlm.nih.gov/pubmed/37259469 http://dx.doi.org/10.3390/ph16020327 |
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