Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery

Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract. Conventional organic acids or enteric coating polymers cannot address this problem adequately because they leach out or dissolve prematurely, especially during co...

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Detalles Bibliográficos
Autores principales: Chang, Hao Han R., Chen, Kuan, Lugtu-Pe, Jamie Anne, AL-Mousawi, Nour, Zhang, Xuning, Bar-Shalom, Daniel, Kane, Anil, Wu, Xiao Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964771/
https://www.ncbi.nlm.nih.gov/pubmed/36839869
http://dx.doi.org/10.3390/pharmaceutics15020547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964771/
https://www.ncbi.nlm.nih.gov/pubmed/36839869
http://dx.doi.org/10.3390/pharmaceutics15020547

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