Cargando…

Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization

Cancer stemness is the process by which cancer cells acquire chemoresistance and self-renewal in the tumor microenvironment. Glucose-regulated protein 78 (GRP78) is a biomarker for gastric cancer and is involved in cancer stemness. By inducing cancer stemness in various types of cancer, the polariza...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jen-Lung, Tai, Yun-Shen, Tsai, Hsin-Yi, Hsieh, Chia-Yuan, Chen, Chun-Lin, Liu, Chung-Jung, Wu, Deng-Chyang, Huang, Yaw-Bin, Lin, Ming-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964887/ https://www.ncbi.nlm.nih.gov/pubmed/36838713 http://dx.doi.org/10.3390/molecules28041725

Ejemplares similares

Ultrasensitive Detection of GRP78 in Exosomes and Observation of Migration and Proliferation of Cancer Cells by Application of GRP78-Containing Exosomes
por: Tsurusawa, Naoko, et al.
Publicado: (2022)

Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
por: Zheng, Yifeng, et al.
Publicado: (2019)

Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear Cholesteatoma Growth
por: Ho, Kuen Yao, et al.
Publicado: (2013)

Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation
por: Lee, Chien-Hsing, et al.
Publicado: (2022)

Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78
por: Cai, Youli, et al.
Publicado: (2018)

GRP78 inhibits macrophage adhesion via SR-A
por: Bai, Hui, et al.
Publicado: (2014)

Gastric Cancer Cell-Derived Exosomal GRP78 Enhances Angiogenesis upon Stimulation of Vascular Endothelial Cells
por: Iha, Kanako, et al.
Publicado: (2022)

The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness
por: Chen, Hsin-Ying, et al.
Publicado: (2018)

The meta and bioinformatics analysis of GRP78 expression in gastric cancer
por: Zheng, Hua-Chuan, et al.
Publicado: (2017)

GRP78 in lung cancer
por: Xia, Shengkai, et al.
Publicado: (2021)

Differential requirement of GRP94 and GRP78 in mammary gland development
por: Zhu, Genyuan, et al.
Publicado: (2014)

Potential to Eradicate Cancer Stemness by Targeting Cell Surface GRP78
por: Chen, Hsin-Ying, et al.
Publicado: (2022)

Mitochondrial metabolic regulation by GRP78
por: Prasad, Manoj, et al.
Publicado: (2017)

Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation
por: Hu, Fang-Wei, et al.
Publicado: (2017)

GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells
por: Ibanez, Jorge, et al.
Publicado: (2023)

Galectin-1 binds GRP78 to promote the proliferation and metastasis of gastric cancer
por: Zhang, Qi, et al.
Publicado: (2022)

Grp78 promotes the invasion of hepatocellular carcinoma
por: Su, Rongjian, et al.
Publicado: (2010)

GRP78 at the Centre of the Stage in Cancer and Neuroprotection
por: Casas, Caty
Publicado: (2017)

Targeting the GRP78 Pathway for Cancer Therapy
por: Lu, Guanhua, et al.
Publicado: (2020)

GRP78: A cell's response to stress
por: Ibrahim, Ibrahim M., et al.
Publicado: (2019)

High-Molecular-Weight Hyaluronic Acid Inhibits IL-1β-Induced Synovial Inflammation and Macrophage Polarization through the GRP78-NF-κB Signaling Pathway
por: Lee, Chien-Hsing, et al.
Publicado: (2021)

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma
por: Steiner, Normann, et al.
Publicado: (2017)

Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer: Lanatoside C suppresses GRP78 stress induction
por: Ha, Dat P., et al.
Publicado: (2021)

Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs
por: Hughes, Scott J., et al.
Publicado: (2016)

Enterovirus 71 induces dsRNA/PKR-dependent cytoplasmic redistribution of GRP78/BiP to promote viral replication
por: Jheng, Jia-Rong, et al.
Publicado: (2016)

Involvement of Membrane GRP78 in Trophoblastic Cell Fusion
por: Fradet, Sarah, et al.
Publicado: (2012)

The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System
por: Hebert-Schuster, Marylise, et al.
Publicado: (2018)

Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro
por: ZHANG, XINCHEN, et al.
Publicado: (2015)

The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
por: Du, Tongde, et al.
Publicado: (2019)

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection
por: Carlos, Anthony J., et al.
Publicado: (2021)

Correction: Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs
por: Hughes, Scott J, et al.
Publicado: (2016)

Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways
por: La, Xiaoqin, et al.
Publicado: (2018)

Berberine Attenuates Macrophages Infiltration in Intracranial Aneurysms Potentially Through FAK/Grp78/UPR Axis
por: Quan, Kai, et al.
Publicado: (2018)

Co-downregulation of GRP78 and GRP94 Induces Apoptosis and Inhibits Migration in Prostate Cancer Cells
por: Lu, Tong, et al.
Publicado: (2019)

Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer
por: Chen, Jack, et al.
Publicado: (2022)

GRP78 Is a Targetable Receptor on Cancer and Stromal Cells
por: Araujo, Nathalia, et al.
Publicado: (2018)

GRP78 targeting: Hitting two birds with a stone
por: Elfiky, Abdo A., et al.
Publicado: (2020)

GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica
por: Shimizu, Fumitaka, et al.
Publicado: (2019)

ILDR2 stabilization is regulated by its interaction with GRP78
por: Watanabe, Kazuhisa, et al.
Publicado: (2021)

COVID-19, Obesity, and GRP78: Unraveling the Pathological Link
por: Shin, Jihoon, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dcqbd3s6hag75msueq63f2oa8m