A Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of the Dopamine Receptor Antagonist LE300 and Its N-methyl Metabolite in Plasma: Application to a Pharmacokinetic Study

LE300 is a novel dopamine receptor antagonist used to treat cocaine addiction. In the current study, a sensitive and fast liquid chromatography–tandem mass spectrometry (LC-MS/MS) has been established and validated for the simultaneous analysis of LE300 and its N-methyl metabolite, MLE300, in rat pl...

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Detalles Bibliográficos
Autores principales: Hefnawy, Mohamed M., Attwa, Mohamed W., Alzamil, Adeeba A., El-Gendy, Manal A., El-Azab, Adel S., Jardan, Yousef A. Bin, El-Gamal, Ali A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964957/
https://www.ncbi.nlm.nih.gov/pubmed/36838539
http://dx.doi.org/10.3390/molecules28041553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964957/
https://www.ncbi.nlm.nih.gov/pubmed/36838539
http://dx.doi.org/10.3390/molecules28041553

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