New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation

New sets of ibuprofen and indomethacin conjugates comprising triazolyl heterocycle were synthesized via click chemistry, adopting an optimized protocol through the molecular hybridization approach affording the targeted agents in good yields. The new non-steroidal anti-inflammatory drug (NSAID) conj...

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Detalles Bibliográficos
Autores principales: Bokhtia, Riham M., Panda, Siva S., Girgis, Adel S., Samir, Nermin, Said, Mona F., Abdelnaser, Anwar, Nasr, Soad, Bekheit, Mohamed S., Dawood, Abdelhameed S., Sharma, Horrick, Wade, Margaret, Sharma, Swapnil K., Ghanim, Amany M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965125/
https://www.ncbi.nlm.nih.gov/pubmed/36838932
http://dx.doi.org/10.3390/molecules28041945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965125/
https://www.ncbi.nlm.nih.gov/pubmed/36838932
http://dx.doi.org/10.3390/molecules28041945

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