Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation

Bosutinib (BOS) is FDA approved drug for the treatment of chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). We report a fast, sensitive, and simple LC-MS/MS method, validated for the determination of BOS in human liver microsomes, utilizing tofacitinib (TO...

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Detalles Bibliográficos
Autores principales: Attwa, Mohamed W., Alanazi, Mohammed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965169/
https://www.ncbi.nlm.nih.gov/pubmed/36838629
http://dx.doi.org/10.3390/molecules28041641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965169/
https://www.ncbi.nlm.nih.gov/pubmed/36838629
http://dx.doi.org/10.3390/molecules28041641

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