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Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation

Bosutinib (BOS) is FDA approved drug for the treatment of chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). We report a fast, sensitive, and simple LC-MS/MS method, validated for the determination of BOS in human liver microsomes, utilizing tofacitinib (TO...

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Detalles Bibliográficos
Autores principales:	Attwa, Mohamed W., Alanazi, Mohammed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965169/ https://www.ncbi.nlm.nih.gov/pubmed/36838629 http://dx.doi.org/10.3390/molecules28041641

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