Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation

Sphingosine 1-phosphate (S1P) lyase (SPL, Sgpl1) is an ER-associated enzyme that irreversibly degrades the bioactive lipid, S1P, and thereby regulates multiple cellular functions attributed to S1P. Biallelic mutations in the human Sglp1 gene lead to a severe form of a particular steroid-resistant ne...

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Detalles Bibliográficos
Autores principales: Imeri, Faik, Stepanovska Tanturovska, Bisera, Manaila, Roxana, Pavenstädt, Hermann, Pfeilschifter, Josef, Huwiler, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965238/
https://www.ncbi.nlm.nih.gov/pubmed/36834691
http://dx.doi.org/10.3390/ijms24043267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965238/
https://www.ncbi.nlm.nih.gov/pubmed/36834691
http://dx.doi.org/10.3390/ijms24043267

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