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Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation

Sphingosine 1-phosphate (S1P) lyase (SPL, Sgpl1) is an ER-associated enzyme that irreversibly degrades the bioactive lipid, S1P, and thereby regulates multiple cellular functions attributed to S1P. Biallelic mutations in the human Sglp1 gene lead to a severe form of a particular steroid-resistant ne...

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Detalles Bibliográficos
Autores principales:	Imeri, Faik, Stepanovska Tanturovska, Bisera, Manaila, Roxana, Pavenstädt, Hermann, Pfeilschifter, Josef, Huwiler, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965238/ https://www.ncbi.nlm.nih.gov/pubmed/36834691 http://dx.doi.org/10.3390/ijms24043267

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