Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice

Wine and by-products of the winemaking process, such as grape stems, are rich in bioactive polyphenolic compounds that might be beneficial for animal and human health. In recent years, the administration of dietary polyphenols with strong antioxidant and cytoprotective properties has constituted an...

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Autores principales: Tekos, Fotios, Skaperda, Zoi, Vardakas, Periklis, Kyriazi, Despina, Maravelis, Georgios C., Poulas, Konstantinos, Taitzoglou, Ioannis A., Nepka, Charitini, Kouretas, Demetrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965357/
https://www.ncbi.nlm.nih.gov/pubmed/36838560
http://dx.doi.org/10.3390/molecules28041574
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author Tekos, Fotios
Skaperda, Zoi
Vardakas, Periklis
Kyriazi, Despina
Maravelis, Georgios C.
Poulas, Konstantinos
Taitzoglou, Ioannis A.
Nepka, Charitini
Kouretas, Demetrios
author_facet Tekos, Fotios
Skaperda, Zoi
Vardakas, Periklis
Kyriazi, Despina
Maravelis, Georgios C.
Poulas, Konstantinos
Taitzoglou, Ioannis A.
Nepka, Charitini
Kouretas, Demetrios
author_sort Tekos, Fotios
collection PubMed
description Wine and by-products of the winemaking process, such as grape stems, are rich in bioactive polyphenolic compounds that might be beneficial for animal and human health. In recent years, the administration of dietary polyphenols with strong antioxidant and cytoprotective properties has constituted an emerging line of research interest toward disease prevention. However, in scientific literature, only a limited number of studies have investigated the safety and the toxicological risks of polyphenolic compounds in vivo. Based on the above, the purpose of the present study was two-fold: first, to examine the effects of oral administration of a grape stem extract, derived from the Greek red wine Mavrodaphne, on mice redox biomarkers; and second, to investigate the biological effects of oral administration of a wine extract, derived from the emblematic Greek red wine Xinomavro, on rats. Toward this purpose, body weight, growth rate, hematological, biochemical, and histopathological parameters, as well as a panel of redox biomarkers, were examined. According to our results, the administration of Mavrodaphne grape stem extract in mice induced alterations in redox homeostasis, preventing mice from the adverse effects of lipid peroxidation. Contrariwise, the administration of Xinomavro wine extract induced both beneficial and harmful outcomes on rat redox status determined by the examined tissue. Collectively, our study reports that the Mavrodaphne grape stem extract, a serious pollutant when disposed in environmental matrices, is an important source of bioactive polyphenolic compounds that could protect from oxidative damage and improve animal and human health. Finally, the Xinomavro wine extract exerts tissue-specific changes in redox balance, which are indicative of the complexity that characterizes the biological systems.
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spelling pubmed-99653572023-02-26 Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice Tekos, Fotios Skaperda, Zoi Vardakas, Periklis Kyriazi, Despina Maravelis, Georgios C. Poulas, Konstantinos Taitzoglou, Ioannis A. Nepka, Charitini Kouretas, Demetrios Molecules Article Wine and by-products of the winemaking process, such as grape stems, are rich in bioactive polyphenolic compounds that might be beneficial for animal and human health. In recent years, the administration of dietary polyphenols with strong antioxidant and cytoprotective properties has constituted an emerging line of research interest toward disease prevention. However, in scientific literature, only a limited number of studies have investigated the safety and the toxicological risks of polyphenolic compounds in vivo. Based on the above, the purpose of the present study was two-fold: first, to examine the effects of oral administration of a grape stem extract, derived from the Greek red wine Mavrodaphne, on mice redox biomarkers; and second, to investigate the biological effects of oral administration of a wine extract, derived from the emblematic Greek red wine Xinomavro, on rats. Toward this purpose, body weight, growth rate, hematological, biochemical, and histopathological parameters, as well as a panel of redox biomarkers, were examined. According to our results, the administration of Mavrodaphne grape stem extract in mice induced alterations in redox homeostasis, preventing mice from the adverse effects of lipid peroxidation. Contrariwise, the administration of Xinomavro wine extract induced both beneficial and harmful outcomes on rat redox status determined by the examined tissue. Collectively, our study reports that the Mavrodaphne grape stem extract, a serious pollutant when disposed in environmental matrices, is an important source of bioactive polyphenolic compounds that could protect from oxidative damage and improve animal and human health. Finally, the Xinomavro wine extract exerts tissue-specific changes in redox balance, which are indicative of the complexity that characterizes the biological systems. MDPI 2023-02-06 /pmc/articles/PMC9965357/ /pubmed/36838560 http://dx.doi.org/10.3390/molecules28041574 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tekos, Fotios
Skaperda, Zoi
Vardakas, Periklis
Kyriazi, Despina
Maravelis, Georgios C.
Poulas, Konstantinos
Taitzoglou, Ioannis A.
Nepka, Charitini
Kouretas, Demetrios
Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
title Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
title_full Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
title_fullStr Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
title_full_unstemmed Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
title_short Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
title_sort redox biomarkers assessment after oral administration of wine extract and grape stem extract in rats and mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965357/
https://www.ncbi.nlm.nih.gov/pubmed/36838560
http://dx.doi.org/10.3390/molecules28041574
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