Cargando…

Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression

Peroxisome proliferator-activated receptor γ (PPARγ) gene mutations in humans and mice lead to whole-body insulin resistance and partial lipodystrophy. It is unclear whether preserved fat depots in partial lipodystrophy are beneficial for whole-body metabolic homeostasis. We analyzed the insulin res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Cherng-Shyang, Yu, Shang-Shiuan, Ho, Li-Chun, Chao, Shu-Hsin, Chou, Ting-Yu, Shao, Ai-Ning, Kao, Ling-Zhen, Chang, Chia-Yu, Chen, Yu-Hsin, Wu, Ming-Shan, Tsai, Pei-Jane, Maeda, Nobuyo, Tsai, Yau-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966317/ https://www.ncbi.nlm.nih.gov/pubmed/36835312 http://dx.doi.org/10.3390/ijms24043904

Ejemplares similares

Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance
por: Agostini, Maura, et al.
Publicado: (2006)

Quantitative PPARγ expression affects the balance between tolerance and immunity
por: Liu, Ya-Hui, et al.
Publicado: (2016)

Lipodystrophic laminopathies: Diagnostic clues
por: Guillín-Amarelle, Cristina, et al.
Publicado: (2018)

SUN-037 Diagnosis Challenge in Type 4 Familial Partial Lipodystrophic Syndrome
por: Vantyghem, Marie-Christine, et al.
Publicado: (2019)

Inhibitory effect of PPARγ on NLRP3 inflammasome activation
por: Yang, Ching-Chun, et al.
Publicado: (2021)

Irisin levels in LMNA-mutated lipodystrophic syndromes
por: Bensmaine, Faiza, et al.
Publicado: (2015)

Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice
por: Wilson, Anne, et al.
Publicado: (2018)

Perforated Sigmoid Colon Cancer within an Irreducible Inguinal Hernia: a Case Report
por: Ko, Kai-Hsiung, et al.
Publicado: (2010)

PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells
por: Karnati, Srikanth, et al.
Publicado: (2018)

Myostatin inhibition improves hyperglycemia and hyperphagia in lipodystrophic mice
por: Guo, Tingqing, et al.
Publicado: (2012)

PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity
por: Chen, Ju-Yi, et al.
Publicado: (2021)

JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice
por: Pandey, Rahul, et al.
Publicado: (2021)

Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α(+) Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis
por: Tseng, Hsin-Han, et al.
Publicado: (2022)

Activation of Sphingolipid Pathway in the Livers of Lipodystrophic Agpat2(−/−) Mice
por: Sankella, Shireesha, et al.
Publicado: (2017)

Leptin treatment has vasculo-protective effects in lipodystrophic mice
por: Stürzebecher, Paulina Elena, et al.
Publicado: (2022)

Electroacupuncture Regulates Inguinal White Adipose Tissue Browning by Promoting Sirtuin-1-Dependent PPARγ Deacetylation and Mitochondrial Biogenesis
por: Tang, Qianqian, et al.
Publicado: (2021)

Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism
por: Kroker, Alice J., et al.
Publicado: (2015)

Adherence with metreleptin therapy and health self-perception in patients with lipodystrophic syndromes
por: Vatier, Camille, et al.
Publicado: (2019)

OR17-01 Leptin Decreases De Novo Lipogenesis in Lipodystrophic Patients
por: Baykal, Annah Petek, et al.
Publicado: (2020)

Leptin Improves Parameters of Brown Adipose Tissue Thermogenesis in Lipodystrophic Mice
por: Hoffmann, Annett, et al.
Publicado: (2021)

Effects of PPARγ and RBP4 Gene Variants on Metabolic Syndrome in HIV-Infected Patients with Anti-Retroviral Therapy
por: Hung, Yuan-Pin, et al.
Publicado: (2012)

Association of the PPAR-γ Gene with Altered Glucose Levels and Psychosis Profile in Schizophrenia Patients Exposed to Antipsychotics
por: Liu, Yun-Ru, et al.
Publicado: (2014)

Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice
por: Girousse, Amandine, et al.
Publicado: (2018)

Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
por: Elzeneini, Eman, et al.
Publicado: (2017)

HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy
por: Lee, Ting-I, et al.
Publicado: (2016)

Dietician-based approach to lipodystrophic syndrome: role of bioelectrical impedance analysis at week 12
por: Orofino, G, et al.
Publicado: (2010)

Defective Differentiation of Adipose Precursor Cells from Lipodystrophic Mice Lacking Perilipin 1
por: Lyu, Ying, et al.
Publicado: (2015)

Recombinant human leptin treatment in genetic lipodystrophic syndromes: the long-term Spanish experience
por: Araujo-Vilar, David, et al.
Publicado: (2014)

PPAR-γ Partial Agonists in Disease-Fate Decision with Special Reference to Cancer
por: Ballav, Sangeeta, et al.
Publicado: (2022)

Kocuria varians infection associated with brain abscess: A case report
por: Tsai, Cheng-Yu, et al.
Publicado: (2010)

The PPARγ‐SETD8 axis constitutes an epigenetic, p53‐independent checkpoint on p21‐mediated cellular senescence
por: Shih, Chieh‐Tien, et al.
Publicado: (2017)

A glimpse of the connection between PPARγ and macrophage
por: Yu, Lexiang, et al.
Publicado: (2023)

The role and function of PPARγ in bladder cancer
por: Peng, Tianchen, et al.
Publicado: (2020)

Pparg-P465L Mutation Worsens Hyperglycemia in Ins2-Akita Female Mice via Adipose-Specific Insulin Resistance and Storage Dysfunction
por: Pendse, Avani A., et al.
Publicado: (2010)

Solubilization Behavior of Homopolymer in Its Blend with the Block Copolymer Displaying the Feature of Lower Critical Ordering Transition
por: Lin, Yu-Hsuan, et al.
Publicado: (2021)

Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1–6 cells
por: Jeng, Kuo-Shyang, et al.
Publicado: (2013)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity
por: Ayza, Muluken Altaye, et al.
Publicado: (2020)

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists
por: Liberato, Marcelo Vizoná, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_r24pd4v9kdc3punuesphfbtrq5