P16(INK4a) Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy

Neonatal mice achieve complete cardiac repair through endogenous myocardial regeneration after apical resection (AR), but this capacity is rapidly lost 7 days after birth. As an upstream inhibitor of cyclin-dependent kinase 4/6- (CDK4/6-) mediated cell cycle activity, p16(INK4a) is widely involved i...

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Detalles Bibliográficos
Autores principales: Sun, Jiateng, Zhou, Liuhua, Yang, Tongtong, Deng, Bo, Bao, Yulin, Gu, Lingfeng, Wang, Hao, Wang, Liansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966567/
https://www.ncbi.nlm.nih.gov/pubmed/36852326
http://dx.doi.org/10.1155/2023/1696190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966567/
https://www.ncbi.nlm.nih.gov/pubmed/36852326
http://dx.doi.org/10.1155/2023/1696190

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