Evolutionary Couplings and Molecular Dynamic Simulations Highlight Details of GPCRs Heterodimers’ Interfaces

A growing body of evidence suggests that only a few amino acids (“hot-spots”) at the interface contribute most of the binding energy in transient protein-protein interactions. However, experimental protocols to identify these hot-spots are highly labor-intensive and expensive. Computational methods,...

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Detalles Bibliográficos
Autores principales: Nchourupouo, Karim Widad Temgbet, Nde, Jules, Ngouongo, Yannick Joel Wadop, Zekeng, Serge Sylvain, Fongang, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966702/
https://www.ncbi.nlm.nih.gov/pubmed/36838825
http://dx.doi.org/10.3390/molecules28041838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966702/
https://www.ncbi.nlm.nih.gov/pubmed/36838825
http://dx.doi.org/10.3390/molecules28041838

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