Pyrrolyldihydropyrazino[1,2-a]indoletrione Analogue Microtubule Inhibitor Induces Cell-Cycle Arrest and Apoptosis in Colorectal Cancer Cells

In this study, 2-benzyl-10a-(1H-pyrrol-2-yl)-2,3-dihydropyrazino[1,2-a]indole-1,4,10(10aH)-trione (DHPITO), a previously identified inhibitor against hepatocellular carcinoma cells, is shown to exert its cytotoxic effects by suppressing the proliferation and growth of CRC cells. An investigation of...

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Detalles Bibliográficos
Autores principales: Yang, Dong-Lin, Qin, Hong-Xia, Zhang, Na-Na, Zhang, Ya-Jun, Huang, Jiu-Hong, Hu, Chun-Sheng, Zhang, Xiao-Xue, Li, Yong, He, Liu-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966721/
https://www.ncbi.nlm.nih.gov/pubmed/36838936
http://dx.doi.org/10.3390/molecules28041948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966721/
https://www.ncbi.nlm.nih.gov/pubmed/36838936
http://dx.doi.org/10.3390/molecules28041948

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