Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for (203)Pb and (212)Pb-Based Theranostics

(203)Pb and (212)Pb have emerged as promising theranostic isotopes for image-guided α-particle radionuclide therapy for cancers. Here, we report a cyclen-based Pb specific chelator (PSC) that is conjugated to tyr(3)-octreotide via a PEG(2) linker (PSC-PEG-T) targeting somatostatin receptor subtype 2...

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Detalles Bibliográficos
Autores principales: Li, Mengshi, Baumhover, Nicholas J., Liu, Dijie, Cagle, Brianna S., Boschetti, Frédéric, Paulin, Guillaume, Lee, Dongyoul, Dai, Zhiming, Obot, Ephraim R., Marks, Brenna M., Okeil, Ibrahim, Sagastume, Edwin A., Gabr, Moustafa, Pigge, F. Christopher, Johnson, Frances L., Schultz, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966725/
https://www.ncbi.nlm.nih.gov/pubmed/36839736
http://dx.doi.org/10.3390/pharmaceutics15020414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966725/
https://www.ncbi.nlm.nih.gov/pubmed/36839736
http://dx.doi.org/10.3390/pharmaceutics15020414

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