Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome driven pyroptotic cell death. We recently reported that the danger-associated molecular pattern (DAMP) oxidized mitochondrial DNA (ox-mtDNA)...

Descripción completa

Detalles Bibliográficos
Autores principales: Ward, Grace A., Dalton, Robert P., Meyer, Benjamin S., McLemore, Amy F., Aldrich, Amy L., Lam, Nghi B., Onimus, Alexis H., Vincelette, Nicole D., Trinh, Thu Le, Chen, Xianghong, Calescibetta, Alexandra R., Christiansen, Sean M., Hou, Hsin-An, Johnson, Joseph O., Wright, Kenneth L., Padron, Eric, Eksioglu, Erika A., List, Alan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966808/
https://www.ncbi.nlm.nih.gov/pubmed/36835307
http://dx.doi.org/10.3390/ijms24043896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966808/
https://www.ncbi.nlm.nih.gov/pubmed/36835307
http://dx.doi.org/10.3390/ijms24043896

Ejemplares similares