Cargando…

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome driven pyroptotic cell death. We recently reported that the danger-associated molecular pattern (DAMP) oxidized mitochondrial DNA (ox-mtDNA)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ward, Grace A., Dalton, Robert P., Meyer, Benjamin S., McLemore, Amy F., Aldrich, Amy L., Lam, Nghi B., Onimus, Alexis H., Vincelette, Nicole D., Trinh, Thu Le, Chen, Xianghong, Calescibetta, Alexandra R., Christiansen, Sean M., Hou, Hsin-An, Johnson, Joseph O., Wright, Kenneth L., Padron, Eric, Eksioglu, Erika A., List, Alan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966808/ https://www.ncbi.nlm.nih.gov/pubmed/36835307 http://dx.doi.org/10.3390/ijms24043896

Ejemplares similares

Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes
por: McLemore, Amy F., et al.
Publicado: (2022)

Dual pyroptotic biomarkers predict erythroid response in lower-risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin
por: Wang, Chen, et al.
Publicado: (2021)

Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC
por: Dalton, Robert, et al.
Publicado: (2021)

S100A9-induced overexpression of PD-1/PD-L1 contributes to ineffective hematopoiesis in myelodysplastic syndromes
por: Cheng, Pinyang, et al.
Publicado: (2019)

Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes
por: Sallman, David A., et al.
Publicado: (2021)

Immunodepletion of MDSC by AMV564, a novel bivalent, bispecific CD33/CD3 T cell engager, ex vivo in MDS and melanoma
por: Cheng, Pingyan, et al.
Publicado: (2022)

Book Review
por: McLemore, Luke
Publicado: (2010)

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4
por: McNeela, Edel A., et al.
Publicado: (2010)

Prognostic Value of NLRP3 Inflammasome and TLR4 Expression in Breast Cancer Patients
por: Saponaro, Concetta, et al.
Publicado: (2021)

Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS Phenotype
por: Sallman, David A., et al.
Publicado: (2016)

The NLRP6 inflammasome
por: Zheng, Danping, et al.
Publicado: (2020)

Spotlight on the NLRP3 inflammasome pathway
por: Groslambert, Marine, et al.
Publicado: (2018)

TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles)
por: Xing, Y, et al.
Publicado: (2016)

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
por: Yang, Junling, et al.
Publicado: (2020)

The NLRP1 inflammasome in skin diseases
por: Burian, Marc, et al.
Publicado: (2023)

The role of the NLRP3 inflammasome in gout
por: Kingsbury, Sarah R, et al.
Publicado: (2011)

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
por: Kang, Seokwon, et al.
Publicado: (2015)

TLR4 Enhances Cerebral Ischemia/Reperfusion Injury via Regulating NLRP3 Inflammasome and Autophagy
por: Mao, Li, et al.
Publicado: (2023)

Neurodegenerative Disease and the NLRP3 Inflammasome
por: Holbrook, Jonathan A., et al.
Publicado: (2021)

MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma
por: Kandell, Wendy M., et al.
Publicado: (2020)

Inhibiting the NLRP3 Inflammasome
por: El-Sharkawy, Lina Y., et al.
Publicado: (2020)

Immune dysregulation in myelodysplastic syndrome
por: Sugimori, Chiharu, et al.
Publicado: (2010)

The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice
por: Tsutsui, Hiroko, et al.
Publicado: (2010)

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages
por: Zhang, Hui, et al.
Publicado: (2016)

TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation
por: Wu, Hui-Mei, et al.
Publicado: (2020)

Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome
por: Hu, Yang, et al.
Publicado: (2019)

Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production
por: Molagoda, Ilandarage Menu Neelaka, et al.
Publicado: (2021)

CD38 Enhances TLR9 Expression and Activates NLRP3 Inflammasome after Porcine Parvovirus Infection
por: Zheng, Yi, et al.
Publicado: (2022)

Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway
por: Liang, Xuemei, et al.
Publicado: (2023)

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
por: Gurung, Prajwal, et al.
Publicado: (2015)

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome
por: Zhang, Tan, et al.
Publicado: (2021)

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
por: Saresella, Marina, et al.
Publicado: (2016)

Staphylococcus aureus increases Prostaglandin E(2) secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways
por: Zhang, Kai, et al.
Publicado: (2023)

The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney
por: Kim, Yang Gyun, et al.
Publicado: (2019)

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
por: de Carvalho, Renan V. H., et al.
Publicado: (2019)

Severe COVID-19: NLRP3 Inflammasome Dysregulated
por: van den Berg, Daan F., et al.
Publicado: (2020)

hTERT deficiency in naïve T cells affects lymphocyte homeostasis in myelodysplastic syndrome patients
por: Yang, Lili, et al.
Publicado: (2013)

Data from three prospective longitudinal human cohorts of prenatal marijuana exposure and offspring outcomes from the fetal period through young adulthood
por: McLemore, Gabrielle L., et al.
Publicado: (2016)

Editorial Introduction
por: Chen, Zhuo, et al.
Publicado: (2022)

The Role of the NLRP3 Inflammasome in Fibrosis
por: Artlett, Carol M
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_a48pb3oc2pi1gtpn8na7tl20ic