Development of Novel siRNA Therapeutics: A Review with a Focus on Inclisiran for the Treatment of Hypercholesterolemia

Over the past two decades, it was discovered that introducing synthetic small interfering RNAs (siRNAs) into the cytoplasm facilitates effective gene-targeted silencing. This compromises gene expression and regulation by repressing transcription or stimulating sequence-specific RNA degradation. Subs...

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Detalles Bibliográficos
Autores principales: Ebenezer, Oluwakemi, Comoglio, Pietro, Wong, Gane Ka-Shu, Tuszynski, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966809/
https://www.ncbi.nlm.nih.gov/pubmed/36835426
http://dx.doi.org/10.3390/ijms24044019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966809/
https://www.ncbi.nlm.nih.gov/pubmed/36835426
http://dx.doi.org/10.3390/ijms24044019

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