Cargando…

Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice

Patients with inactive thyroid hormone (TH) transporter MCT8 display intellectual disability due to compromised central TH transport and action. As a therapeutic strategy, application of thyromimetic, MCT8-independent compounds Triac (3,5,3′-triiodothyroacetic acid), and Ditpa (3,5-diiodo-thyropropi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jiesi, Salveridou, Eva, Liebmann, Lutz, Sundaram, Sivaraj M., Doycheva, Denica, Markova, Boyka, Hübner, Christian A., Boelen, Anita, Visser, W. Edward, Heuer, Heike, Mayerl, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966820/ https://www.ncbi.nlm.nih.gov/pubmed/36834863 http://dx.doi.org/10.3390/ijms24043452

Ejemplares similares

Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration
por: Mayerl, Steffen, et al.
Publicado: (2018)

Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function
por: Siemes, Devon, et al.
Publicado: (2023)

TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
por: Reinwald, Jonathan Rochus, et al.
Publicado: (2022)

Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development
por: Mayerl, Steffen, et al.
Publicado: (2021)

Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis
por: Mayerl, Steffen, et al.
Publicado: (2022)

OR01-05 Long-Term Efficacy of T3 Analogue Triac in MCT8 Deficiency
por: van Geest, Ferdy S, et al.
Publicado: (2020)

Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8
por: Bárez-López, Soledad, et al.
Publicado: (2019)

Triacs y tiristores
por: Bergtold, Fritz
Publicado: (1981)

Tiristores y triacs
por: Lilen, Henri
Publicado: (1996)

Triacs y tiristores
por: Bergtold, Fritz

Thyristors et triacs
por: Lilen, Henri
Publicado: (1971)

Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal Development
por: Kowallick, Mirjam, et al.
Publicado: (2021)

OR14-02 The Thyroid Hormone Analogs DITPA And TRIAC Triggered T3-signalling In Human MCT8-deficient Brain Organoids
por: Salas Lucia, Federico, et al.
Publicado: (2023)

Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study
por: van Geest, Ferdy S, et al.
Publicado: (2021)

Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone
por: Luongo, Cristina, et al.
Publicado: (2021)

The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes
por: Schnell, Christian, et al.
Publicado: (2013)

Circuitos integrados para tiristores y triacs
por: Couëdic, Marc
Publicado: (2000)

Circuitos con triacs, diacs y tiristores
por: Bergtold, Fritz
Publicado: (1981)

SCR manual: including triacs and other thyristors
por: Grafham, D R, et al.
Publicado: (1979)

Gene therapy targeting the blood–brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency
por: Sundaram, Sivaraj M, et al.
Publicado: (2022)

Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10)
por: Sharlin, David S., et al.
Publicado: (2018)

Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome
por: Maity-Kumar, Gandhari, et al.
Publicado: (2022)

Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain
por: De Angelis, Meri, et al.
Publicado: (2022)

Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Pyramidal Neurons and Interneurons in the Adult Motor Cortex of Human and Macaque Brain
por: Wang, Yu, et al.
Publicado: (2023)

Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains
por: Wang, Ting, et al.
Publicado: (2023)

Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling
por: Mayerl, Steffen, et al.
Publicado: (2020)

Insights Into the Mechanism of MCT8 Oligomerization
por: Groeneweg, Stefan, et al.
Publicado: (2020)

Structure of human drug transporters OATP1B1 and OATP1B3
por: Ciută, Anca-Denise, et al.
Publicado: (2023)

TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs
por: Yamauchi, Ichiro, et al.
Publicado: (2023)

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1
por: Nies, Anne T, et al.
Publicado: (2013)

Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions
por: Kayesh, Ruhul, et al.
Publicado: (2023)

Thyristoren und Triacs: wie sie arbeiten, wofür man sie braucht, wie man sie schaltet
por: Richter, Heinz
Publicado: (1969)

Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions
por: Alam, Khondoker, et al.
Publicado: (2018)

Transcriptional Regulation of Liver-Type OATP1B3 (Lt-OATP1B3) and Cancer-Type OATP1B3 (Ct-OATP1B3) Studied in Hepatocyte-Derived and Colon Cancer-Derived Cell Lines
por: Haberkorn, Bastian, et al.
Publicado: (2023)

Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10
por: Porst, Theresa, et al.
Publicado: (2021)

Inhibition of Hypothalamic MCT4 and MCT1–MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions
por: Elizondo-Vega, Roberto, et al.
Publicado: (2019)

Prevalence of Virulence Genes Among Bulgarian Nosocomial and Cystic Fibrosis Isolates of Pseudomonas Aeruginosa
por: Mitov, Ivan, et al.
Publicado: (2010)

Ginsenoside Rb1 and Rd Remarkably Inhibited the Hepatic Uptake of Ophiopogonin D in Shenmai Injection Mediated by OATPs/oatps
por: Liu, Xiaopei, et al.
Publicado: (2018)

Selectivity and Potency of Microcystin Congeners against OATP1B1 and OATP1B3 Expressing Cancer Cells
por: Niedermeyer, Timo H. J., et al.
Publicado: (2014)

Role of OATP1B1 and OATP1B3 in Drug-Drug Interactions Mediated by Tyrosine Kinase Inhibitors
por: Garrison, Dominique A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mta4193cfavuh1fee0v9cm65ut