Rational Design of Profile HMMs for Sensitive and Specific Sequence Detection with Case Studies Applied to Viruses, Bacteriophages, and Casposons

Profile hidden Markov models (HMMs) are a powerful way of modeling biological sequence diversity and constitute a very sensitive approach to detecting divergent sequences. Here, we report the development of protocols for the rational design of profile HMMs. These methods were implemented on TABAJARA...

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Detalles Bibliográficos
Autores principales: Oliveira, Liliane S., Reyes, Alejandro, Dutilh, Bas E., Gruber, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966878/
https://www.ncbi.nlm.nih.gov/pubmed/36851733
http://dx.doi.org/10.3390/v15020519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966878/
https://www.ncbi.nlm.nih.gov/pubmed/36851733
http://dx.doi.org/10.3390/v15020519

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