Exploring the Chemical Space of CYP17A1 Inhibitors Using Cheminformatics and Machine Learning

Cytochrome P450 17A1 (CYP17A1) is one of the key enzymes in steroidogenesis that produces dehydroepiandrosterone (DHEA) from cholesterol. Abnormal DHEA production may lead to the progression of severe diseases, such as prostatic and breast cancers. Thus, CYP17A1 is a druggable target for anti-cancer...

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Detalles Bibliográficos
Autores principales: Yu, Tianshi, Huang, Tianyang, Yu, Leiye, Nantasenamat, Chanin, Anuwongcharoen, Nuttapat, Piacham, Theeraphon, Ren, Ruobing, Chiang, Ying-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966999/
https://www.ncbi.nlm.nih.gov/pubmed/36838665
http://dx.doi.org/10.3390/molecules28041679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966999/
https://www.ncbi.nlm.nih.gov/pubmed/36838665
http://dx.doi.org/10.3390/molecules28041679

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