The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer

Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification. Chemical modification or the conjugation of therapeutic oligonucleotides is required to increase the...

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Detalles Bibliográficos
Autores principales: Varizhuk, Irina V., Tsvetkov, Vladimir B., Toropygin, Ilya Yu., Stomakhin, Andrey A., Kolganova, Natalia A., Surzhikov, Sergei A., Timofeev, Edward N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967020/
https://www.ncbi.nlm.nih.gov/pubmed/36839926
http://dx.doi.org/10.3390/pharmaceutics15020604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967020/
https://www.ncbi.nlm.nih.gov/pubmed/36839926
http://dx.doi.org/10.3390/pharmaceutics15020604

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