Interaction of Camptothecin Anticancer Drugs with Ribosomal Proteins L15 and L11: A Molecular Docking Study

The antitumor drug topotecan (TPT) is a potent inhibitor of topoisomerase I, triggering DNA breaks lethal for proliferating cancer cells. The mechanism is common to camptothecins SN38 (the active metabolite of irinotecan) and belotecan (BLT). Recently, TPT was shown to bind the ribosomal protein L15...

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Detalles Bibliográficos
Autores principales: Bailly, Christian, Vergoten, Gérard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967338/
https://www.ncbi.nlm.nih.gov/pubmed/36838813
http://dx.doi.org/10.3390/molecules28041828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967338/
https://www.ncbi.nlm.nih.gov/pubmed/36838813
http://dx.doi.org/10.3390/molecules28041828

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